D-learning to estimate optimal individual treatment rules

Statistical learning of origin-specific statically optimal individualized treatment rules.

Consider a longitudinal observational or controlled study in which one collects chronological data over time on a random sample of subjects. The time-dependent process one observes on each subject contains time-dependent covariates, time-dependent treatment actions, and an outcome process or single final outcome of interest. A statically optimal individualized treatment rule (as introduced in v...

C-learning: A new classification framework to estimate optimal dynamic treatment regimes.

A dynamic treatment regime is a sequence of decision rules, each corresponding to a decision point, that determine that next treatment based on each individual's own available characteristics and treatment history up to that point. We show that identifying the optimal dynamic treatment regime can be recast as a sequential optimization problem and propose a direct sequential optimization method ...

Optimal Learning Rules for Dis rete Synapses

Globally Optimal On-line Learning Rules

We present a method for determining the globally optimal on-line learning rule for a soft committee machine under a statistical mechanics framework. This work complements previous results on locally optimal rules, where only the rate of change in generalization error was considered. We maximize the total reduction in generalization error over the whole learning process and show how the resultin...

Optimal Learning Rules for Discrete Synapses

There is evidence that biological synapses have a limited number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights, as old memories are automatically overwritten by new memories. Consequently, there has been substantial discussion about how this affects learning and storage capacity. In this paper, we calculat...